EvolDeeds: uncertainty-display and data-cleaning notes

confidence coloring could be useful, but first: confidence in WHAT exactly. Same width doesn't mean same homology, and missing confidence needs its own color / legend.

uI idea: display confidence on alignment positions or tree nodes, rather than coloring every inferred structure as equally certain. The source identifies react-msaview as supporting MSA/tree display and customizable coloring, with additional implementation potentially needed for confidence views.

Equal alignment width with different homology pairs.
Equal alignment width with different homology pairs.

input cleaning issues from the shared brainstorm: singleton families, duplicate sequences, very short unaligned sequences, nonstandard amino-acid letters and mixed letter case. One contributor used a ten-amino-acid cutoff but explicitly called it project-dependent. Do not silently turn that exploratory threshold into a universal rule.

  • review questions: what posterior statistic defines the displayed confidence? Is uncertainty in column homology comparable across samples with different alignment widths? Are tree-node identifiers stable under topology changes? Preserve a clear legend and distinguish missing/undefined confidence from low confidence.
  • status: visualization proposal, not proof that confidence coloring was implemented. The precise day remains estimated from the working-document period.